Results
| PMID | 16008887 |
| Gene Name | IL17A |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 62 |
| Population details | 62 (36 patients with different stage endometriosis, 26 patients without endometriosis) |
| Sex | Female |
| Infertility type | Female infertility |
| Associated genes | IL-17 |
| Other associated phenotypes |
Endometriosis, Endometriosis related infertility |
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Zhonghua Fu Chan Ke Za Zhi. 2005 Jun;40(6):380-2. Zhang, Xin-mei| Lin, Jun| Xu, Hong| Deng, Lin| Qian, Yu-li Department of Gynecology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China. OBJECTIVE: To investigate the role of interleukin-17 (IL-17) in the pathogenesis of endometriosis. METHODS: Enzyme-linked immunosorbent assay (ELISA) was used to detect the concentrations of IL-17 in peritoneal fluid of 36 patients with different stage endometriosis and 26 patients without endometriosis. RESULTS: The concentrations of IL-17 in peritoneal fluid of the patients with and without endometriosis were (5.7 +/- 1.9) ng/L and (5.3 +/- 1.4) ng/L, respectively, without significant difference between the two groups (P > 0.05). According to staging criteria of r-AFS, the concentrations of peritoneal IL-17 in the patients with stage I-II endometriosis (6.4 +/- 1.7) ng/L were significantly higher than those in the patients with stage III-IV endometriosis (5.1 +/- 1.8) ng/L and in the patients without endometriosis (P < 0.05). There was no difference with regard to peritoneal IL-17 concentrations between proliferative and secretory phases in the patients with or without endometriosis (P > 0.05). The levels of peritoneal IL-17 were significantly higher in the endometriosis patients with infertility (6.4 +/- 1.8) ng/L than in the endometriosis patients without infertility (5.1 +/- 1.8) ng/L (P < 0.05). CONCLUSION: IL-17 may play an important role in the pathogenesis of early endometriosis and pathophysiology of endometriosis-associated infertility. Mesh Terms: Adult| Ascitic Fluid/*chemistry/metabolism| Endometriosis/*metabolism/pathology| Female| Humans| Infertility, Female/metabolism/pathology| Interleukin-17/*analysis/metabolism| Young Adult|DA 2010/06/04 06:00 |
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